Drug interactions
Atorvastatin + Ceftobiprole medocaril
Severity: Moderate
Atorvastatin and Ceftobiprole medocaril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits hepatic OATP1B1 and OATP1B3 uptake transporters and may raise atorvastatin plasma levels. Higher statin exposure increases the risk of myopathy.
What this interaction means in plain words
Atorvastatin and Ceftobiprole medocaril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ceftobiprole inhibits OATP1B1/1B3-mediated hepatic uptake of atorvastatin.
What to do
Consider temporarily holding or reducing atorvastatin during ceftobiprole therapy, and monitor for muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Ceftobiprole medocaril?
MediHelp rates the interaction as moderate. Atorvastatin and Ceftobiprole medocaril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits hepatic OATP1B1 and OATP1B3 uptake transporters and may raise atorvastatin plasma levels. Higher statin exposure increases the risk of myopathy.
How serious is the interaction between Atorvastatin and Ceftobiprole medocaril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily holding or reducing atorvastatin during ceftobiprole therapy, and monitor for muscle pain or weakness.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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