Drug interactions
Atorvastatin + Dabigatran
Severity: Moderate
Atorvastatin and Dabigatran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin may inhibit P-glycoprotein modestly and raise dabigatran exposure. Dabigatran is a P-gp substrate with a narrow margin in renal impairment, so bleeding risk could increase, although the effect of atorvastatin is small.
What this interaction means in plain words
Atorvastatin and Dabigatran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Atorvastatin weakly inhibits intestinal P-glycoprotein efflux of dabigatran etexilate.
What to do
Monitor for bleeding signs and assess renal function, especially when creatinine clearance is reduced. Follow dabigatran labeling for dose adjustment with P-gp inhibitors in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Dabigatran?
MediHelp rates the interaction as moderate. Atorvastatin and Dabigatran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atorvastatin may inhibit P-glycoprotein modestly and raise dabigatran exposure. Dabigatran is a P-gp substrate with a narrow margin in renal impairment, so bleeding risk could increase, although the effect of atorvastatin is small.
How serious is the interaction between Atorvastatin and Dabigatran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and assess renal function, especially when creatinine clearance is reduced. Follow dabigatran labeling for dose adjustment with P-gp inhibitors in renal impairment.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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