Drug interactions
Atorvastatin + Dabrafenib
Severity: Moderate
Atorvastatin and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and can reduce atorvastatin plasma concentrations. Cholesterol lowering may be weakened.
What this interaction means in plain words
Atorvastatin and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Dabrafenib belongs to Oncology.
Why it happens
Dabrafenib induces CYP3A4, increasing atorvastatin metabolism.
What to do
Monitor lipid response and increase the atorvastatin dose if needed; reassess when dabrafenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Atorvastatin with Dabrafenib?
MediHelp rates the interaction as moderate. Atorvastatin and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and can reduce atorvastatin plasma concentrations. Cholesterol lowering may be weakened.
How serious is the interaction between Atorvastatin and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid response and increase the atorvastatin dose if needed; reassess when dabrafenib is stopped.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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