Drug interactions
Atorvastatin + Encorafenib
Severity: Moderate
Atorvastatin and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4 and inhibits OATP1B1, OATP1B3 and BCRP, all relevant to atorvastatin disposition. Atorvastatin exposure could rise or fall, with myopathy a concern if it increases.
What this interaction means in plain words
Atorvastatin and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Encorafenib belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition/induction plus OATP1B and BCRP inhibition by encorafenib alter atorvastatin clearance.
What to do
Monitor for muscle symptoms and lipid response, and adjust the atorvastatin dose or choose an alternative statin if toxicity or loss of effect occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Atorvastatin with Encorafenib?
MediHelp rates the interaction as moderate. Atorvastatin and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4 and inhibits OATP1B1, OATP1B3 and BCRP, all relevant to atorvastatin disposition. Atorvastatin exposure could rise or fall, with myopathy a concern if it increases.
How serious is the interaction between Atorvastatin and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and lipid response, and adjust the atorvastatin dose or choose an alternative statin if toxicity or loss of effect occurs.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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