Drug interactions
Atorvastatin + Ethinyl estradiol-norgestimate
Severity: Minor
Atorvastatin and Ethinyl estradiol-norgestimate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin given with ethinyl estradiol-containing contraceptives has been reported to increase ethinyl estradiol exposure and, to a greater degree, the exposure of norethindrone-type progestins. The change is generally modest and rarely produces symptoms.
What this interaction means in plain words
Atorvastatin and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Atorvastatin may increase hormone absorption or reduce first-pass clearance, possibly via intestinal transport or metabolism effects; the mechanism is not firmly established.
What to do
No routine dose change is needed; monitor for estrogenic adverse effects such as breast tenderness or nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as minor. Atorvastatin and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin given with ethinyl estradiol-containing contraceptives has been reported to increase ethinyl estradiol exposure and, to a greater degree, the exposure of norethindrone-type progestins. The change is generally modest and rarely produces symptoms.
How serious is the interaction between Atorvastatin and Ethinyl estradiol-norgestimate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for estrogenic adverse effects such as breast tenderness or nausea.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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