Drug interactions
Atorvastatin + Fenofibrate micronized
Severity: Moderate
Atorvastatin and Fenofibrate micronized: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a fibrate with a statin can increase the risk of myopathy and rhabdomyolysis. For fenofibrate the risk is lower than with gemfibrozil, but it still exists.
What this interaction means in plain words
Atorvastatin and Fenofibrate micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myotoxicity of the two drug classes; fenofibrate has little effect on statin glucuronidation or exposure.
What to do
Use only when the lipid benefit justifies it, with the lowest effective doses, and counsel patients to report unexplained muscle pain. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Fenofibrate micronized?
MediHelp rates the interaction as moderate. Atorvastatin and Fenofibrate micronized can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a fibrate with a statin can increase the risk of myopathy and rhabdomyolysis. For fenofibrate the risk is lower than with gemfibrozil, but it still exists.
How serious is the interaction between Atorvastatin and Fenofibrate micronized?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when the lipid benefit justifies it, with the lowest effective doses, and counsel patients to report unexplained muscle pain. Check CK if symptoms occur.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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