Drug interactions
Atorvastatin + Hydrocortisone
Severity: Minor
Atorvastatin and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone may slightly reduce atorvastatin exposure through weak CYP3A4 induction, and corticosteroids can raise lipids and glucose. The net effect on statin efficacy is usually small.
What this interaction means in plain words
Atorvastatin and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atorvastatin belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Weak CYP3A4 induction by hydrocortisone; atorvastatin P-glycoprotein effects on hydrocortisone are of little significance.
What to do
No dose change is routinely required; check lipid profile if long-term systemic corticosteroids are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Hydrocortisone?
MediHelp rates the interaction as minor. Atorvastatin and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone may slightly reduce atorvastatin exposure through weak CYP3A4 induction, and corticosteroids can raise lipids and glucose. The net effect on statin efficacy is usually small.
How serious is the interaction between Atorvastatin and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; check lipid profile if long-term systemic corticosteroids are used.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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