Drug interactions
Atorvastatin + Isoniazid
Severity: Moderate
Atorvastatin and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may modestly raise atorvastatin levels via CYP3A4 inhibition, and both drugs can affect the liver. This may increase the risk of myopathy or transaminase elevation.
What this interaction means in plain words
Atorvastatin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Isoniazid belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by isoniazid increasing atorvastatin exposure, with additive hepatotoxic potential.
What to do
Monitor liver enzymes and ask patients to report unexplained muscle pain or weakness. Use the lowest effective atorvastatin dose during isoniazid therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Isoniazid?
MediHelp rates the interaction as moderate. Atorvastatin and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may modestly raise atorvastatin levels via CYP3A4 inhibition, and both drugs can affect the liver. This may increase the risk of myopathy or transaminase elevation.
How serious is the interaction between Atorvastatin and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and ask patients to report unexplained muscle pain or weakness. Use the lowest effective atorvastatin dose during isoniazid therapy.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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