Drug interactions
Atorvastatin + Ledipasvir / sofosbuvir
Severity: Moderate
Atorvastatin and Ledipasvir / sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir can raise statin concentrations, so atorvastatin exposure may increase. This raises the risk of myopathy including rhabdomyolysis.
What this interaction means in plain words
Atorvastatin and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ledipasvir inhibits OATP1B and BCRP transporters, increasing atorvastatin exposure.
What to do
Monitor closely for muscle pain, weakness and CK elevation, and consider a lower atorvastatin dose or temporary hold.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Ledipasvir / sofosbuvir?
MediHelp rates the interaction as moderate. Atorvastatin and Ledipasvir / sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir can raise statin concentrations, so atorvastatin exposure may increase. This raises the risk of myopathy including rhabdomyolysis.
How serious is the interaction between Atorvastatin and Ledipasvir / sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for muscle pain, weakness and CK elevation, and consider a lower atorvastatin dose or temporary hold.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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