Drug interactions
Atorvastatin + Mestranol
Severity: Minor
Atorvastatin and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin raises exposure of ethinylestradiol-type estrogens modestly, and mestranol is converted to ethinylestradiol. The effect is small and rarely significant.
What this interaction means in plain words
Atorvastatin and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Atorvastatin may modestly increase ethinylestradiol exposure; the mechanism is not clearly established.
What to do
No dose adjustment is usually needed. Watch for estrogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Mestranol?
MediHelp rates the interaction as minor. Atorvastatin and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin raises exposure of ethinylestradiol-type estrogens modestly, and mestranol is converted to ethinylestradiol. The effect is small and rarely significant.
How serious is the interaction between Atorvastatin and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Watch for estrogenic adverse effects.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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