Drug interactions
Atorvastatin + Miconazole vaginal
Severity: Minor
Atorvastatin and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has some systemic absorption and miconazole inhibits CYP3A4, so atorvastatin levels could rise. The effect is probably small with short topical courses but muscle toxicity is possible.
What this interaction means in plain words
Atorvastatin and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Absorbed miconazole inhibits CYP3A4-mediated atorvastatin metabolism.
What to do
Counsel patients to report muscle pain or weakness during treatment. Consider holding atorvastatin only for prolonged or repeated courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Miconazole vaginal?
MediHelp rates the interaction as minor. Atorvastatin and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has some systemic absorption and miconazole inhibits CYP3A4, so atorvastatin levels could rise. The effect is probably small with short topical courses but muscle toxicity is possible.
How serious is the interaction between Atorvastatin and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report muscle pain or weakness during treatment. Consider holding atorvastatin only for prolonged or repeated courses.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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