Drug interactions
Atorvastatin + Mipomersen
Severity: Moderate
Atorvastatin and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes, so combined use may increase hepatotoxicity. The legacy suggestion of an OATP-mediated myopathy effect is not well supported.
What this interaction means in plain words
Atorvastatin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential; mipomersen causes hepatic steatosis and transaminase elevation.
What to do
Monitor ALT, AST and bilirubin at baseline and regularly as per mipomersen labeling. Stop or reduce therapy if enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Mipomersen?
MediHelp rates the interaction as moderate. Atorvastatin and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes, so combined use may increase hepatotoxicity. The legacy suggestion of an OATP-mediated myopathy effect is not well supported.
How serious is the interaction between Atorvastatin and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin at baseline and regularly as per mipomersen labeling. Stop or reduce therapy if enzymes rise significantly.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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