Drug interactions
Atorvastatin + Ponatinib
Severity: Moderate
Atorvastatin and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein and BCRP in vitro and may raise atorvastatin levels. This could increase the risk of myopathy.
What this interaction means in plain words
Atorvastatin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Ponatinib belongs to Oncology.
Why it happens
Ponatinib inhibits intestinal and hepatic transporters such as P-glycoprotein, increasing statin exposure.
What to do
Monitor for muscle pain, weakness or elevated CK. Use the lowest effective atorvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Atorvastatin with Ponatinib?
MediHelp rates the interaction as moderate. Atorvastatin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-glycoprotein and BCRP in vitro and may raise atorvastatin levels. This could increase the risk of myopathy.
How serious is the interaction between Atorvastatin and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness or elevated CK. Use the lowest effective atorvastatin dose.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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