Drug interactions
Atorvastatin + Sacubitril / valsartan
Severity: Moderate
Atorvastatin and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin exposure can rise when it is given with sacubitril/valsartan, which may increase the risk of statin-related muscle toxicity. In the labeling for sacubitril/valsartan, sacubitril is reported to raise atorvastatin and its metabolite levels modestly. The clinical effect is usually small and manageable.
What this interaction means in plain words
Atorvastatin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sacubitril and its active metabolite inhibit hepatic uptake transporters OATP1B1/1B3, reducing hepatic uptake of atorvastatin and raising its plasma concentration.
What to do
Monitor patients for muscle pain, weakness or dark urine and check creatine kinase if symptoms appear. Use the lowest effective atorvastatin dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Atorvastatin and Sacubitril / valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Atorvastatin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atorvastatin exposure can rise when it is given with sacubitril/valsartan, which may increase the risk of statin-related muscle toxicity. In the labeling for sacubitril/valsartan, sacubitril is reported to raise atorvastatin and its metabolite levels modestly. The clinical effect is usually small and manageable.
How serious is the interaction between Atorvastatin and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for muscle pain, weakness or dark urine and check creatine kinase if symptoms appear. Use the lowest effective atorvastatin dose if symptoms develop.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
