Drug interactions
Atorvastatin + Sofosbuvir / velpatasvir
Severity: Major
Atorvastatin and Sofosbuvir / velpatasvir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits OATP1B1, OATP1B3 and OATP2B1 and can substantially raise atorvastatin concentrations. This increases the risk of myopathy including rhabdomyolysis.
What this interaction means in plain words
Atorvastatin and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Velpatasvir inhibits hepatic OATP uptake transporters, increasing atorvastatin exposure.
What to do
Monitor closely for muscle symptoms and CK, and consider a lower atorvastatin dose or temporary interruption during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as major. Atorvastatin and Sofosbuvir / velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Velpatasvir inhibits OATP1B1, OATP1B3 and OATP2B1 and can substantially raise atorvastatin concentrations. This increases the risk of myopathy including rhabdomyolysis.
How serious is the interaction between Atorvastatin and Sofosbuvir / velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for muscle symptoms and CK, and consider a lower atorvastatin dose or temporary interruption during treatment.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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