Drug interactions
Atorvastatin + Teniposide
Severity: Minor
Atorvastatin and Teniposide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atorvastatin may inhibit P-glycoprotein and theoretically raise teniposide exposure. Evidence of a clinically meaningful effect is lacking, and the interaction is largely predicted from transporter data.
What this interaction means in plain words
Atorvastatin and Teniposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Atorvastatin may inhibit P-glycoprotein-mediated efflux of teniposide.
What to do
Monitor for teniposide toxicity such as myelosuppression with routine blood counts during chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Danazol Major
Frequently asked questions
Can I take Atorvastatin with Teniposide?
MediHelp rates the interaction as minor. Atorvastatin and Teniposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atorvastatin may inhibit P-glycoprotein and theoretically raise teniposide exposure. Evidence of a clinically meaningful effect is lacking, and the interaction is largely predicted from transporter data.
How serious is the interaction between Atorvastatin and Teniposide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for teniposide toxicity such as myelosuppression with routine blood counts during chemotherapy.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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