Drug interactions
Atracurium + Cevimeline
Severity: Minor
Atracurium and Cevimeline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cevimeline is a muscarinic agonist taken orally for dry mouth, whereas atracurium is a nondepolarizing neuromuscular blocker acting at nicotinic receptors. Any opposition to blockade is theoretical and poorly documented.
What this interaction means in plain words
Atracurium and Cevimeline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atracurium belongs to Musculoskeletal; Cevimeline belongs to Miscellaneous.
Why it happens
Theoretical cholinergic pharmacodynamic opposition; cevimeline is mainly muscarinic and the clinical effect on nicotinic blockade is not established.
What to do
Monitor depth of neuromuscular blockade with train-of-four during surgery in patients taking cevimeline and titrate atracurium to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Other interactions of Cevimeline
- Amitriptyline + Cevimeline Moderate
- Atenolol-chlorthalidone + Cevimeline Moderate
- Atenolol + Cevimeline Moderate
- Atropine + Cevimeline Moderate
- Betaxolol + Cevimeline Moderate
- Bethanechol + Cevimeline Moderate
Frequently asked questions
Can I take Atracurium with Cevimeline?
MediHelp rates the interaction as minor. Atracurium and Cevimeline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cevimeline is a muscarinic agonist taken orally for dry mouth, whereas atracurium is a nondepolarizing neuromuscular blocker acting at nicotinic receptors. Any opposition to blockade is theoretical and poorly documented.
How serious is the interaction between Atracurium and Cevimeline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depth of neuromuscular blockade with train-of-four during surgery in patients taking cevimeline and titrate atracurium to effect.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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