Drug interactions
Atracurium + Dosulepin
Severity: Minor
Atracurium and Dosulepin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin has anticholinergic properties but no established meaningful effect on the action of non-depolarizing neuromuscular blockers. Any interaction with atracurium is theoretical.
What this interaction means in plain words
Atracurium and Dosulepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atracurium belongs to Musculoskeletal; Dosulepin belongs to Central Nervous System.
Why it happens
No established mechanism; proposed pharmacodynamic link is unsupported by clear evidence.
What to do
No dose adjustment is needed; use routine neuromuscular monitoring during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Atracurium
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Atracurium with Dosulepin?
MediHelp rates the interaction as minor. Atracurium and Dosulepin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dosulepin has anticholinergic properties but no established meaningful effect on the action of non-depolarizing neuromuscular blockers. Any interaction with atracurium is theoretical.
How serious is the interaction between Atracurium and Dosulepin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; use routine neuromuscular monitoring during anesthesia.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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