Drug interactions
Atracurium + Oxytetracycline
Severity: Moderate
Atracurium and Oxytetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines have weak neuromuscular blocking effects, and potentiation of nondepolarising blockers is described mainly in case reports. Clinical significance with oxytetracycline is likely small but could prolong recovery.
What this interaction means in plain words
Atracurium and Oxytetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Oxytetracycline belongs to Anti Bacterial.
Why it happens
Possible calcium chelation and weak presynaptic neuromuscular blockade adding to nondepolarising blockade.
What to do
Monitor neuromuscular function with train-of-four during surgery or ICU use. Adjust atracurium dosing to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atracurium
Other interactions of Oxytetracycline
- Isotretinoin + Oxytetracycline Contraindicated
- Aluminum hydroxide + Oxytetracycline Moderate
- Ampicillin-sulbactam + Oxytetracycline Moderate
- Ampicillin + Oxytetracycline Moderate
- Bismuth subsalicylate + Oxytetracycline Moderate
- Calcium carbonate + Oxytetracycline Moderate
Frequently asked questions
Can I take Atracurium with Oxytetracycline?
MediHelp rates the interaction as moderate. Atracurium and Oxytetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracyclines have weak neuromuscular blocking effects, and potentiation of nondepolarising blockers is described mainly in case reports. Clinical significance with oxytetracycline is likely small but could prolong recovery.
How serious is the interaction between Atracurium and Oxytetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four during surgery or ICU use. Adjust atracurium dosing to response.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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