Drug interactions
Atracurium + Prednisolone
Severity: Moderate
Atracurium and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids given with neuromuscular blockers are associated with acute myopathy and prolonged weakness, mainly in critically ill patients receiving prolonged blockade. Atracurium may carry somewhat lower risk than aminosteroid blockers, but caution is still needed.
What this interaction means in plain words
Atracurium and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Prednisolone belongs to Endocrine.
Why it happens
Additive skeletal muscle toxicity; the exact mechanism of acute myopathy is not fully established.
What to do
Use the shortest effective duration and lowest dose of each drug and monitor neuromuscular function. Check creatine kinase if prolonged weakness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Atracurium
Frequently asked questions
Can I take Atracurium with Prednisolone?
MediHelp rates the interaction as moderate. Atracurium and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids given with neuromuscular blockers are associated with acute myopathy and prolonged weakness, mainly in critically ill patients receiving prolonged blockade. Atracurium may carry somewhat lower risk than aminosteroid blockers, but caution is still needed.
How serious is the interaction between Atracurium and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest effective duration and lowest dose of each drug and monitor neuromuscular function. Check creatine kinase if prolonged weakness occurs.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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