Drug interactions
Atropine iv / + Clozapine
Severity: Moderate
Atropine iv / and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combined use can increase tachycardia, constipation, urinary retention, confusion and ileus. Clozapine can cause hypersalivation, and atropine is sometimes used to treat this, which makes cumulative anticholinergic burden a particular concern.
What this interaction means in plain words
Atropine iv / and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Use the lowest effective atropine dose and monitor heart rate, bowel function, urinary retention and mental status. Avoid prolonged combined use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Atropine iv / with Clozapine?
MediHelp rates the interaction as moderate. Atropine iv / and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, so combined use can increase tachycardia, constipation, urinary retention, confusion and ileus. Clozapine can cause hypersalivation, and atropine is sometimes used to treat this, which makes cumulative anticholinergic burden a particular concern.
How serious is the interaction between Atropine iv / and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective atropine dose and monitor heart rate, bowel function, urinary retention and mental status. Avoid prolonged combined use where possible.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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