Drug interactions
Atropine iv / + Cyclobenzaprine
Severity: Moderate
Atropine iv / and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parenteral atropine is a potent antimuscarinic and cyclobenzaprine has considerable anticholinergic effects. Together they may cause tachycardia, urinary retention, dry mouth, confusion and hyperthermia.
What this interaction means in plain words
Atropine iv / and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor heart rate, mental status and urinary function, and be cautious in older patients or those with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Atropine iv / with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Atropine iv / and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral atropine is a potent antimuscarinic and cyclobenzaprine has considerable anticholinergic effects. Together they may cause tachycardia, urinary retention, dry mouth, confusion and hyperthermia.
How serious is the interaction between Atropine iv / and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, mental status and urinary function, and be cautious in older patients or those with glaucoma or urinary obstruction.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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