Drug interactions
Axicabtagene ciloleucel + Baricitinib
Severity: Major
Axicabtagene ciloleucel and Baricitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baricitinib may impair CAR T-cell expansion and function and adds to infection risk after lymphodepleting therapy. This may reduce the efficacy of the cell product.
What this interaction means in plain words
Axicabtagene ciloleucel and Baricitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Baricitinib belongs to Musculoskeletal.
Why it happens
JAK inhibition suppresses T-cell activation and proliferation, potentially blunting CAR T-cell activity.
What to do
Avoid baricitinib around leukapheresis and CAR T infusion unless essential. Coordinate with the oncology team and monitor for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Baricitinib?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Baricitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baricitinib may impair CAR T-cell expansion and function and adds to infection risk after lymphodepleting therapy. This may reduce the efficacy of the cell product.
How serious is the interaction between Axicabtagene ciloleucel and Baricitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid baricitinib around leukapheresis and CAR T infusion unless essential. Coordinate with the oncology team and monitor for infection.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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