Drug interactions
Axicabtagene ciloleucel + Hydrocortisone
Severity: Moderate
Axicabtagene ciloleucel and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids can suppress the T-cell activity on which CAR-T therapy depends, potentially reducing expansion and efficacy, and they add to infection risk. They are, however, standard treatment for cytokine release syndrome and neurotoxicity.
What this interaction means in plain words
Axicabtagene ciloleucel and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axicabtagene ciloleucel belongs to Oncology; Hydrocortisone belongs to Endocrine.
Why it happens
Glucocorticoid-mediated lymphocyte suppression may impair CAR-T cell expansion and persistence.
What to do
Avoid prophylactic or premedication corticosteroids around infusion unless clearly required. Use corticosteroids for cytokine release syndrome or neurologic toxicity as per protocol and monitor for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Hydrocortisone?
MediHelp rates the interaction as moderate. Axicabtagene ciloleucel and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids can suppress the T-cell activity on which CAR-T therapy depends, potentially reducing expansion and efficacy, and they add to infection risk. They are, however, standard treatment for cytokine release syndrome and neurotoxicity.
How serious is the interaction between Axicabtagene ciloleucel and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prophylactic or premedication corticosteroids around infusion unless clearly required. Use corticosteroids for cytokine release syndrome or neurologic toxicity as per protocol and monitor for infection.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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