Drug interactions
Axitinib + Bexarotene
Severity: Moderate
Axitinib and Bexarotene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene induces CYP3A4, which is the main pathway of axitinib clearance. Axitinib exposure may fall, potentially reducing antitumor efficacy.
What this interaction means in plain words
Axitinib and Bexarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Bexarotene belongs to Oncology.
Why it happens
Bexarotene induces CYP3A4, increasing axitinib metabolism.
What to do
Monitor for reduced axitinib response and consider an alternative to bexarotene when feasible; adjust axitinib dosing by tolerability and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Bexarotene + Bosentan Moderate
Frequently asked questions
Can I take Axitinib with Bexarotene?
MediHelp rates the interaction as moderate. Axitinib and Bexarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene induces CYP3A4, which is the main pathway of axitinib clearance. Axitinib exposure may fall, potentially reducing antitumor efficacy.
How serious is the interaction between Axitinib and Bexarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced axitinib response and consider an alternative to bexarotene when feasible; adjust axitinib dosing by tolerability and response.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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