Drug interactions
Axitinib + Cenobamate
Severity: Moderate
Axitinib and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and can reduce axitinib exposure. This may lead to loss of antitumor effect.
What this interaction means in plain words
Axitinib and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Cenobamate belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP3A4, accelerating axitinib clearance.
What to do
Monitor for reduced response and consider a stepwise axitinib dose increase with tolerability monitoring. Lower the dose again if cenobamate is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Axitinib with Cenobamate?
MediHelp rates the interaction as moderate. Axitinib and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and can reduce axitinib exposure. This may lead to loss of antitumor effect.
How serious is the interaction between Axitinib and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and consider a stepwise axitinib dose increase with tolerability monitoring. Lower the dose again if cenobamate is discontinued.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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