Drug interactions
Axitinib + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Axitinib and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4, the main metabolic route of axitinib, which can increase axitinib exposure and its adverse effects such as hypertension, hepatotoxicity and bleeding.
What this interaction means in plain words
Axitinib and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits CYP3A4/5-mediated clearance of axitinib.
What to do
Avoid if possible; otherwise reduce the axitinib dose (labeling suggests roughly halving with strong CYP3A4 inhibitors) and monitor blood pressure and liver function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Axitinib and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat inhibits CYP3A4, the main metabolic route of axitinib, which can increase axitinib exposure and its adverse effects such as hypertension, hepatotoxicity and bleeding.
How serious is the interaction between Axitinib and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the axitinib dose (labeling suggests roughly halving with strong CYP3A4 inhibitors) and monitor blood pressure and liver function.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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