Drug interactions
Axitinib + Encorafenib
Severity: Moderate
Axitinib and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib has mixed effects on CYP3A4, inhibiting and inducing it, so axitinib exposure could rise or fall unpredictably. This may lead to either increased toxicity such as hypertension or reduced antitumor efficacy.
What this interaction means in plain words
Axitinib and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Encorafenib belongs to Oncology.
Why it happens
Encorafenib both inhibits and induces CYP3A4, the main enzyme metabolizing axitinib.
What to do
Monitor blood pressure and tolerability, and assess disease response during coadministration. Adjust the axitinib dose according to toxicity or loss of effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Axitinib with Encorafenib?
MediHelp rates the interaction as moderate. Axitinib and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib has mixed effects on CYP3A4, inhibiting and inducing it, so axitinib exposure could rise or fall unpredictably. This may lead to either increased toxicity such as hypertension or reduced antitumor efficacy.
How serious is the interaction between Axitinib and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability, and assess disease response during coadministration. Adjust the axitinib dose according to toxicity or loss of effect.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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