Drug interactions
Axitinib + Etoposide
Severity: Minor
Axitinib and Etoposide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide is a minor CYP3A4 substrate and not a meaningful CYP3A4 inhibitor, so a clinically relevant rise in axitinib exposure is unlikely. Overlapping myelosuppression or other toxicities are possible but not specific to this pair.
What this interaction means in plain words
Axitinib and Etoposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Etoposide belongs to Oncology.
Why it happens
No well-established mechanism; CYP3A4 inhibition by etoposide is not clinically recognized.
What to do
No dose adjustment is needed. Monitor routine blood counts and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Etoposide?
MediHelp rates the interaction as minor. Axitinib and Etoposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etoposide is a minor CYP3A4 substrate and not a meaningful CYP3A4 inhibitor, so a clinically relevant rise in axitinib exposure is unlikely. Overlapping myelosuppression or other toxicities are possible but not specific to this pair.
How serious is the interaction between Axitinib and Etoposide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor routine blood counts and tolerability.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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