Drug interactions
Axitinib + Glimepiride-pioglitazone
Severity: Minor
Axitinib and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is a weak CYP3A4 inducer in vitro and may lower axitinib exposure, although clinical significance is uncertain.
What this interaction means in plain words
Axitinib and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction by pioglitazone increasing axitinib metabolism.
What to do
No dose change is routinely required; monitor for reduced axitinib efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Axitinib and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pioglitazone is a weak CYP3A4 inducer in vitro and may lower axitinib exposure, although clinical significance is uncertain.
How serious is the interaction between Axitinib and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; monitor for reduced axitinib efficacy.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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