Drug interactions
Axitinib + Hydrocortisone
Severity: Minor
Axitinib and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is metabolized mainly by CYP3A4, and hydrocortisone is a weak inducer that could modestly lower axitinib exposure. The clinical impact is probably small.
What this interaction means in plain words
Axitinib and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Hydrocortisone belongs to Endocrine.
Why it happens
Weak CYP3A4 induction by hydrocortisone may increase axitinib clearance.
What to do
No dose adjustment is normally needed; monitor tumor response and tolerability when prolonged systemic steroids are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Hydrocortisone?
MediHelp rates the interaction as minor. Axitinib and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is metabolized mainly by CYP3A4, and hydrocortisone is a weak inducer that could modestly lower axitinib exposure. The clinical impact is probably small.
How serious is the interaction between Axitinib and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed; monitor tumor response and tolerability when prolonged systemic steroids are used.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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