Drug interactions
Axitinib + Ibuprofen / famotidine
Severity: Minor
Axitinib and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which could theoretically reduce axitinib absorption. Axitinib solubility is only modestly pH dependent, so a clinically important effect is unlikely.
What this interaction means in plain words
Axitinib and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Famotidine increases gastric pH, which may slightly reduce axitinib dissolution.
What to do
No routine adjustment is needed. Monitor treatment response if acid suppression is long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Axitinib and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine raises gastric pH, which could theoretically reduce axitinib absorption. Axitinib solubility is only modestly pH dependent, so a clinically important effect is unlikely.
How serious is the interaction between Axitinib and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor treatment response if acid suppression is long term.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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