Drug interactions
Axitinib + Isoniazid
Severity: Moderate
Axitinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid is a weak to moderate CYP3A4 inhibitor, and axitinib is metabolized mainly by CYP3A4. Exposure to axitinib may rise modestly, which increases the risk of hypertension, diarrhea and other adverse effects.
What this interaction means in plain words
Axitinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4 by isoniazid reduces axitinib metabolism.
What to do
Monitor blood pressure and tolerability of axitinib during isoniazid therapy. Reduce the axitinib dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Isoniazid?
MediHelp rates the interaction as moderate. Axitinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid is a weak to moderate CYP3A4 inhibitor, and axitinib is metabolized mainly by CYP3A4. Exposure to axitinib may rise modestly, which increases the risk of hypertension, diarrhea and other adverse effects.
How serious is the interaction between Axitinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability of axitinib during isoniazid therapy. Reduce the axitinib dose if adverse effects emerge.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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