Drug interactions
Axitinib + Lansoprazole
Severity: Minor
Axitinib and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lansoprazole is at most a weak CYP3A4 inhibitor, so any increase in axitinib exposure is expected to be small. Axitinib is mainly cleared by CYP3A4, and strong inhibitors are the main concern.
What this interaction means in plain words
Axitinib and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Weak, theoretical CYP3A4 inhibition by lansoprazole.
What to do
No dose change is needed; monitor for axitinib adverse effects such as hypertension and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Lansoprazole?
MediHelp rates the interaction as minor. Axitinib and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lansoprazole is at most a weak CYP3A4 inhibitor, so any increase in axitinib exposure is expected to be small. Axitinib is mainly cleared by CYP3A4, and strong inhibitors are the main concern.
How serious is the interaction between Axitinib and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for axitinib adverse effects such as hypertension and diarrhea.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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