Drug interactions
Axitinib + Metronidazole
Severity: Minor
Axitinib and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is only a weak CYP3A4 inhibitor, so a clinically important rise in axitinib exposure is unlikely. Any effect would be modest.
What this interaction means in plain words
Axitinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
Weak inhibition of CYP3A4 may slightly reduce axitinib metabolism.
What to do
No dose change is usually required. Monitor for axitinib adverse effects such as hypertension and diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Metronidazole?
MediHelp rates the interaction as minor. Axitinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is only a weak CYP3A4 inhibitor, so a clinically important rise in axitinib exposure is unlikely. Any effect would be modest.
How serious is the interaction between Axitinib and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor for axitinib adverse effects such as hypertension and diarrhea.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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