Drug interactions
Axitinib + Pentobarbital
Severity: Moderate
Axitinib and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital can reduce axitinib plasma levels and potentially compromise its antitumor effect.
What this interaction means in plain words
Axitinib and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturates induce CYP3A4, increasing axitinib clearance.
What to do
Avoid long-term use of barbiturates where possible and choose a non-inducing alternative. If unavoidable, monitor for reduced efficacy and consider axitinib dose increases as tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Pentobarbital?
MediHelp rates the interaction as moderate. Axitinib and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital can reduce axitinib plasma levels and potentially compromise its antitumor effect.
How serious is the interaction between Axitinib and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term use of barbiturates where possible and choose a non-inducing alternative. If unavoidable, monitor for reduced efficacy and consider axitinib dose increases as tolerated.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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