Drug interactions
Axitinib + Phenobarbital
Severity: Moderate
Axitinib and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital can lower axitinib exposure through enzyme induction, risking loss of antitumor efficacy.
What this interaction means in plain words
Axitinib and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenobarbital induces CYP3A4, increasing axitinib metabolism.
What to do
Use a non-inducing anticonvulsant or sedative where possible. If unavoidable, monitor tumor response and consider axitinib dose increases as tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Phenobarbital?
MediHelp rates the interaction as moderate. Axitinib and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital can lower axitinib exposure through enzyme induction, risking loss of antitumor efficacy.
How serious is the interaction between Axitinib and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant or sedative where possible. If unavoidable, monitor tumor response and consider axitinib dose increases as tolerated.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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