Drug interactions
Axitinib + Topiramate
Severity: Minor
Axitinib and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is mainly metabolized by CYP3A4, and topiramate is a weak inducer that may modestly lower axitinib exposure. Reduced exposure could in theory diminish antitumor effect, but the interaction is likely small.
What this interaction means in plain words
Axitinib and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Topiramate belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by topiramate may increase axitinib clearance.
What to do
No routine adjustment is needed. Monitor tumor response and blood pressure, and consider an alternative antiseizure drug if efficacy is a concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Topiramate?
MediHelp rates the interaction as minor. Axitinib and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is mainly metabolized by CYP3A4, and topiramate is a weak inducer that may modestly lower axitinib exposure. Reduced exposure could in theory diminish antitumor effect, but the interaction is likely small.
How serious is the interaction between Axitinib and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor tumor response and blood pressure, and consider an alternative antiseizure drug if efficacy is a concern.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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