Drug interactions
Azapropazone + Enoxaparin
Severity: Moderate
Azapropazone and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azapropazone is an NSAID that impairs platelet function and can cause gastrointestinal bleeding, so it adds to bleeding risk with enoxaparin. Its use is now very restricted.
What this interaction means in plain words
Azapropazone and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from NSAID platelet inhibition and mucosal injury plus enoxaparin anticoagulation.
What to do
Avoid if possible and choose a non-NSAID analgesic such as paracetamol. If combined, monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Azapropazone with Enoxaparin?
MediHelp rates the interaction as moderate. Azapropazone and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azapropazone is an NSAID that impairs platelet function and can cause gastrointestinal bleeding, so it adds to bleeding risk with enoxaparin. Its use is now very restricted.
How serious is the interaction between Azapropazone and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose a non-NSAID analgesic such as paracetamol. If combined, monitor for bleeding.
What other medicines interact with Enoxaparin?
MediHelp also lists interactions of Enoxaparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Enoxaparin page.
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