Drug interactions
Azathioprine + Measles mumps and rubella vaccine live
Severity: Contraindicated
Azathioprine and Measles mumps and rubella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This live attenuated combination vaccine may cause disseminated infection in patients immunosuppressed by azathioprine. Immune response may also be inadequate.
What this interaction means in plain words
Azathioprine and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Azathioprine impairs cellular immunity, allowing replication of live attenuated viruses.
What to do
Do not give during azathioprine therapy; vaccinate at least four weeks before starting if possible. Check immunity by serology and use immunoglobulin after exposure.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Azathioprine with Measles mumps and rubella vaccine live?
MediHelp rates the interaction as contraindicated. Azathioprine and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. This live attenuated combination vaccine may cause disseminated infection in patients immunosuppressed by azathioprine. Immune response may also be inadequate.
How serious is the interaction between Azathioprine and Measles mumps and rubella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give during azathioprine therapy; vaccinate at least four weeks before starting if possible. Check immunity by serology and use immunoglobulin after exposure.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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