Drug interactions
Azelastine + Belladonna and opium
Severity: Moderate
Azelastine and Belladonna and opium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine can cause sedation, particularly with oral use or heavier intranasal dosing. Combined with the opium component, CNS and respiratory depression may be increased, and the anticholinergic belladonna adds to drowsiness and confusion.
What this interaction means in plain words
Azelastine and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the antihistamine and the opioid.
What to do
Monitor for excessive sedation and respiratory depression, and start with the lowest effective opioid dose. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Belladonna and opium?
MediHelp rates the interaction as moderate. Azelastine and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine can cause sedation, particularly with oral use or heavier intranasal dosing. Combined with the opium component, CNS and respiratory depression may be increased, and the anticholinergic belladonna adds to drowsiness and confusion.
How serious is the interaction between Azelastine and Belladonna and opium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and start with the lowest effective opioid dose. Advise patients to avoid driving and alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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