Drug interactions
Azelastine + Butabarbital
Severity: Moderate
Azelastine and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are strong CNS depressants and azelastine can add to drowsiness and psychomotor impairment. The combination may result in excessive sedation and, at high doses, respiratory depression.
What this interaction means in plain words
Azelastine and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 receptor antagonism.
What to do
Monitor for oversedation and reduce barbiturate dose if needed. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Butabarbital?
MediHelp rates the interaction as moderate. Azelastine and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are strong CNS depressants and azelastine can add to drowsiness and psychomotor impairment. The combination may result in excessive sedation and, at high doses, respiratory depression.
How serious is the interaction between Azelastine and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce barbiturate dose if needed. Advise patients to avoid driving and alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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