Drug interactions
Azelastine + Butorphanol
Severity: Moderate
Azelastine and Butorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butorphanol is an opioid agonist-antagonist with notable sedative effects. Combined with azelastine it may produce additive drowsiness and respiratory depression.
What this interaction means in plain words
Azelastine and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Butorphanol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid receptor activity and H1-receptor antagonism.
What to do
Use the lowest effective butorphanol dose and monitor sedation and respiratory rate. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Azelastine with Butorphanol?
MediHelp rates the interaction as moderate. Azelastine and Butorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butorphanol is an opioid agonist-antagonist with notable sedative effects. Combined with azelastine it may produce additive drowsiness and respiratory depression.
How serious is the interaction between Azelastine and Butorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective butorphanol dose and monitor sedation and respiratory rate. Counsel patients to avoid driving and alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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