Drug interactions
Azelastine + Chlordiazepoxide
Severity: Moderate
Azelastine and Chlordiazepoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlordiazepoxide is a long-acting benzodiazepine, and azelastine may increase drowsiness. The combination can impair alertness and coordination, particularly in older adults.
What this interaction means in plain words
Azelastine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Chlordiazepoxide belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-receptor antagonism and benzodiazepine enhancement of GABA-A activity.
What to do
Advise against driving and alcohol use, and monitor older patients for sedation and falls. Consider a non-sedating nasal option if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Azelastine with Chlordiazepoxide?
MediHelp rates the interaction as moderate. Azelastine and Chlordiazepoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlordiazepoxide is a long-acting benzodiazepine, and azelastine may increase drowsiness. The combination can impair alertness and coordination, particularly in older adults.
How serious is the interaction between Azelastine and Chlordiazepoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against driving and alcohol use, and monitor older patients for sedation and falls. Consider a non-sedating nasal option if needed.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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