Drug interactions
Azelastine + Clemastine
Severity: Moderate
Azelastine and Clemastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine, and combining it with azelastine duplicates H1 blockade. This raises the likelihood of drowsiness, dry mouth and impaired performance.
What this interaction means in plain words
Azelastine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Clemastine belongs to Respiratory.
Why it happens
Additive H1-receptor antagonism with CNS depressant and anticholinergic effects.
What to do
Avoid duplicate antihistamine therapy where possible. If both are used, counsel on drowsiness and monitor for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Clemastine
Frequently asked questions
Can I take Azelastine with Clemastine?
MediHelp rates the interaction as moderate. Azelastine and Clemastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine, and combining it with azelastine duplicates H1 blockade. This raises the likelihood of drowsiness, dry mouth and impaired performance.
How serious is the interaction between Azelastine and Clemastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate antihistamine therapy where possible. If both are used, counsel on drowsiness and monitor for anticholinergic effects.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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