Drug interactions
Azelastine + Clonidine
Severity: Moderate
Azelastine and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and azelastine (especially the nasal spray) may add to the drowsiness and lowered alertness caused by clonidine. Clonidine can also cause hypotension and bradycardia, but the added effect from azelastine is mainly CNS depression.
What this interaction means in plain words
Azelastine and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Clonidine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic CNS depressant effects.
What to do
Monitor for excessive sedation and psychomotor impairment, and warn the patient about driving and operating machinery. Reduce azelastine use or consider a less sedating antihistamine if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Azelastine with Clonidine?
MediHelp rates the interaction as moderate. Azelastine and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and azelastine (especially the nasal spray) may add to the drowsiness and lowered alertness caused by clonidine. Clonidine can also cause hypotension and bradycardia, but the added effect from azelastine is mainly CNS depression.
How serious is the interaction between Azelastine and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and psychomotor impairment, and warn the patient about driving and operating machinery. Reduce azelastine use or consider a less sedating antihistamine if drowsiness is troublesome.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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