Drug interactions
Azelastine + Dextroamphetamine
Severity: Minor
Azelastine and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may cause drowsiness while dextroamphetamine is a stimulant, so their effects on alertness oppose each other. The net effect is unpredictable and no important clinical interaction is firmly established.
What this interaction means in plain words
Azelastine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine belongs to Respiratory; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic mechanism.
What to do
No routine action is needed; monitor the patient's alertness and do not rely on the stimulant to offset sedation from azelastine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Azelastine with Dextroamphetamine?
MediHelp rates the interaction as minor. Azelastine and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine may cause drowsiness while dextroamphetamine is a stimulant, so their effects on alertness oppose each other. The net effect is unpredictable and no important clinical interaction is firmly established.
How serious is the interaction between Azelastine and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor the patient's alertness and do not rely on the stimulant to offset sedation from azelastine.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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