Drug interactions
Azelastine + Diamorphine
Severity: Moderate
Azelastine and Diamorphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diamorphine (heroin) is a potent opioid, and azelastine may add to sedation and impaired alertness. Additive CNS and respiratory depression is possible.
What this interaction means in plain words
Azelastine and Diamorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism.
What to do
Monitor sedation and respiratory rate, titrating the opioid carefully. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Diamorphine?
MediHelp rates the interaction as moderate. Azelastine and Diamorphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diamorphine (heroin) is a potent opioid, and azelastine may add to sedation and impaired alertness. Additive CNS and respiratory depression is possible.
How serious is the interaction between Azelastine and Diamorphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, titrating the opioid carefully. Avoid alcohol and other sedatives.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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