Drug interactions
Azelastine + Flurazepam
Severity: Moderate
Azelastine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic with prolonged active metabolites. Adding azelastine may increase sedation, impaired coordination and next-day drowsiness.
What this interaction means in plain words
Azelastine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and histamine H1 blockade.
What to do
Monitor for oversedation and psychomotor impairment, particularly in older adults. Consider a non-sedating antihistamine or intranasal alternative when appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Flurazepam?
MediHelp rates the interaction as moderate. Azelastine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic with prolonged active metabolites. Adding azelastine may increase sedation, impaired coordination and next-day drowsiness.
How serious is the interaction between Azelastine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and psychomotor impairment, particularly in older adults. Consider a non-sedating antihistamine or intranasal alternative when appropriate.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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