Drug interactions
Azelastine + Kava
Severity: Moderate
Azelastine and Kava: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Kava has sedative and anxiolytic effects and has been associated with hepatotoxicity. With azelastine it may increase drowsiness and impair psychomotor function.
What this interaction means in plain words
Azelastine and Kava can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABAergic activity of kavalactones and H1 blockade.
What to do
Advise avoiding kava while using sedating antihistamines. Counsel against driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Frequently asked questions
Can I take Azelastine with Kava?
MediHelp rates the interaction as moderate. Azelastine and Kava can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Kava has sedative and anxiolytic effects and has been associated with hepatotoxicity. With azelastine it may increase drowsiness and impair psychomotor function.
How serious is the interaction between Azelastine and Kava?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding kava while using sedating antihistamines. Counsel against driving if drowsy.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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